Inter-zonal epithelial thickness differences for early keratoconus detection using optical coherence tomography.

ABSTRACT:

Purpose

To develop and test a parameter for early keratoconus screening by quantifying the localized epithelial thickness differences in keratoconic eyes.

Methods

The cross-sectional study included 189 eyes of 116 subjects in total: 86 eyes of 54 keratoconus patients with bilateral ectasia and 40 eyes of 20 healthy subjects in the parameter-development dataset and 42 eyes of 21 keratoconus patients with asymmetric ectasia and 21 eyes of 21 healthy subjects in the parameter-validation dataset. Epithelial thickness maps were obtained using anterior segment optical coherence tomography and the inter-zonal epithelial thickness differences were calculated. The developed parameter was tested in keratoconus patients with asymmetric ectasia.

Results

Compared to healthy contro

SUBMITTER: Naujokaitis T 

PROVIDER: S-EPMC11461491 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature