Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity.

ABSTRACT: Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy. However, the overexpression of SLC7A11 promotes glutathione biosynthesis for maintaining redox balance and countering pyroptosis. Herein, we develop intermetallics modified with glucose oxidase (GOx) and soybean phospholipid (SP) as pyroptosis promoters (Pd₂Sn@GOx-SP), that not only induce pyroptosis by cascade biocatalysis for remodeling tumor microenvironment and facilitating tumor cell immunogenicity, but also trigger disulfidptosis mediated by cystine accumulation to further promote tumor pyroptosis in female mice. Experiments and density functional theory calculations show that Pd₂Sn

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11461493 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature