Pre-pregnancy BMI, gestational weight gain, and telomere length in amniotic fluid: a causal graph analysis.

ABSTRACT: Previous investigations have suggested a potential association between pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with telomere length (TL) in various tissues of pregnant women and newborns. Nonetheless, as association does not imply causation, our objective was to investigate the causal connections among pre-pregnancy BMI, GWG, and TL in amniotic fluid. The analysis included 136 mother-child pairs from the Mamma & Bambino cohort, and three causal graph models were developed to depict the interconnections between pre-pregnancy BMI, GWG, and TL. Causal graph analysis was conducted utilizing the do-operator to estimate the causal effect of GWG and the controlled direct effect of pregestational BMI. We revealed that transitioning from non-adequate to adequate GWG ha

SUBMITTER: Barchitta M 

PROVIDER: S-EPMC11461511 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature