RNA-sequencing expression profile and functional analysis of retinal pigment epithelium in atrophic age-related macular degeneration.

ABSTRACT: The retinal pigment epithelium (RPE) is fundamental to sustaining retinal homeostasis. RPE abnormality leads to visual defects and blindness, including age-related macular degeneration (AMD). Although breakthroughs have been made in the treatment of neovascular AMD, effective intervention for atrophic AMD is largely absent. The adequate knowledge of RPE pathology is hindered by a lack of the patients' RPE datasets, especially at the single-cell resolution. In the current study, we delved into a large-scale single-cell resource of AMD donors, in which RPE cells were occupied in a substantial proportion. Bulk RNA-seq datasets of atrophic AMD were integrated to extract molecular characteristics of RPE in the pathogenesis of atrophic AMD. Both in vivo and in vitro models revealed

SUBMITTER: Xu M 

PROVIDER: S-EPMC11461538 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature