Dose-response relationship between serum N-glycan markers and liver fibrosis in chronic hepatitis B.

ABSTRACT:

Background

Evaluation of liver fibrosis played a monumental role in the diagnosis and monitoring of chronic hepatitis B (CHB). We aimed to explore the value of serum N-glycan markers in liver fibrosis.

Methods

This multi-center (33 hospitals) study recruited 760 treatment-naïve CHB patients who underwent liver biopsy. Serum N-glycan markers were analyzed by DNA sequencer-assisted fluorophore-assisted with capillary electrophoresis (DSA-FACE) technology. First, we explore the relationship between 12 serum N-glycan markers and the fibrosis stage. Then, we developed a Px score for diagnosing significant fibrosis using the LASSO regression. Next, we compared the diagnostic performances between Px, LSM, APRI, and FIB-4. Finally, we explored the relationships between glycosyltrans

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11461603 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature