The effect of four loading intravitreal aflibercept injections on macular fluid in treatment-naive neovascular age-related macular degeneration.

ABSTRACT:

Purpose

To evaluate the effect of four versus three loading aflibercept injections on macular fluid resolution and visual acuity (VA) in exudative neovascular AMD (nAMD).

Methods

Multicentre, retrospective cohort study of treatment naïve nAMD eyes undergoing 3 versus 4 loading doses of aflibercept. Change in VA and fluid resolution on optical coherence tomography (OCT), were evaluated at 8 weeks post loading. The primary outcome was proportion of patients with no intraretinal (IRF) and/or subretinal (SRF) fluid at central 1 mm and whole macula at 8 weeks after loading. Data were summarised with mean ± SD for continuous variables, and n (%) for categorical variables.

Results

Data from 995 patients was analysed (355 patients - 4 loading doses and 640-3 loading doses). A

SUBMITTER: Chandra S 

PROVIDER: S-EPMC11461640 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature