Effects of depression and cognitive impairment on increased risks of incident dementia: a prospective study from three elderly cohorts.

ABSTRACT: Depression is usually accompanied with cognitive impairment and increases risk of incident dementia. However, evidence has been limited on the effect size of depression with cognitive impairment and their synergistic effect on future dementia. To explore this, we examined three large cross-country population-based prospective cohorts. Depressive symptoms were assessed by epidemiologic scale, while cognitive impairment was defined by subjective cognitive tests. Dementia was ascertained by self-reported physician-diagnosed conditions. Cox proportional hazard models were employed to determine the hazard ratio (HR) and 95% confidence interval (95% CI), with adjustments of potential confounding variables. Addictive and multiplicative interactions were calculated to evaluate the synergistic effe

SUBMITTER: Yan Y 

PROVIDER: S-EPMC11461656 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature