Nonlinear amplification of nano bowl surface concavity on the critical response threshold to biosignals.

ABSTRACT: Polymer nanoparticles that can sharply sense and detect biological signals in cells are promising candidates for biomedical and theranostic nanomaterials. However, the response ability of current polymer assemblies poorly matches the requirement of trace concentration level (10^-6 ~ 10^-9mol/L) of cellular biosignals due to their linear signal input-to-function output mode, which impedes their practical applications in vivo. Here we report a kind of nanobowl system with pH-tunable invaginated morphology that can nonlinearly amplify the response abilities toward biosignals by modulating the surface concavity. Compared to conventional spherical nanoparticles, nonspherical nanobowls with a specific concave structure reduce the critical response threshold of polymers by up

SUBMITTER: Li X 

PROVIDER: S-EPMC11461742 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature