Validation of drug-nondrug choice procedure to model maladaptive behavioural allocation to opioid use in rats.

ABSTRACT: Increased allocation of behaviour to substance abuse at the expense of personal and social rewards is a hallmark of addiction that is reflected in several of DSM-5 criteria for diagnosis of substance use disorder. Previous studies focused on refining the self-administration (SA) model to better emulate an addictive state in laboratory animals. Here, we employed concurrent SA of sucrose pellets and morphine as two competing natural and drug rewards, respectively, to validate the feasibility of capturing pathological behavioural allocation in rats. A custom-made three-lever operant chamber was used. With one active and one inactive lever presented, rats were trained to self-administer morphine (0.5 mg/kg/infusion; 2 h/day) under a fixed-ratio 1 (FR-1) schedule until a stable response was ach

SUBMITTER: Azizzadeh S 

PROVIDER: S-EPMC11461753 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature