A novel GWAS locus influences microvascular response to mental stress and predicts adverse cardiovascular events.

ABSTRACT: Excessive peripheral microvascular constriction during acute psychological stress reflects similar changes in coronary blood flow and is a predictor of adverse cardiovascular outcomes. Among individuals with coronary artery disease (CAD), we sought to determine if genetic factors contribute to the degree of microvascular constriction during mental stress. A total of 580 stable CAD individuals from two prospective cohort studies underwent mental stress testing. Digital pulse wave amplitude was continuously measured and the stress/rest (sPAT) ratio of pulse wave amplitude was calculated. Race stratified genome-wide association studies (GWAS) of sPAT-ratio were conducted using linear regression of additive genetic models. A trans-ethnic meta-analysis integrated the four sets of GWAS results.

SUBMITTER: Almuwaqqat Z 

PROVIDER: S-EPMC11461842 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature