FAVOR-GPT: a generative natural language interface to whole genome variant functional annotations.

ABSTRACT:

Motivation

Functional Annotation of genomic Variants Online Resources (FAVOR) offers multi-faceted, whole genome variant functional annotations, which is essential for Whole Genome and Exome Sequencing (WGS/WES) analysis and the functional prioritization of disease-associated variants. A versatile chatbot designed to facilitate informative interpretation and interactive, user-centric summary of the whole genome variant functional annotation data in the FAVOR database is needed.

Results

We have developed FAVOR-GPT, a generative natural language interface powered by integrating large language models (LLMs) and FAVOR. It is developed based on the Retrieval Augmented Generation (RAG) approach, and complements the original FAVOR portal, enhancing usability for users, especially t

SUBMITTER: Li TC 

PROVIDER: S-EPMC11461909 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature