Semi-quantitative elemental imaging of corrosion products from bioabsorbable Mg vascular implants in vivo.

ABSTRACT: While metal materials historically have served as permanent implants and were designed to avoid degradation, next generation bioabsorbable metals for medical devices such as vascular stents are under development, which would elute metal ions and corrosion byproducts into tissues. The fate of these eluted products and their local distribution in vascular tissue largely under studied. In this study, we employ a high spatial resolution spectrometric imaging modality, laser ablation inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-TOF-MS) to map the metal distribution, (herein refered to as laser ablation mapping, or LAM) from Mg alloys within the mouse vascular system and approximate their local concentrations. We used a novel rare earth element bearing Mg alloy (WE22) wire

SUBMITTER: He W 

PROVIDER: S-EPMC11462046 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature