Resilience to Chronic Stress Is Characterized by Circadian Brain-Liver Coordination.

ABSTRACT:

Background

Chronic stress has a profound impact on circadian regulation of physiology. In turn, disruption of circadian rhythms increases the risk of developing both psychiatric and metabolic disorders. To explore the role of chronic stress in modulating the links between neural and metabolic rhythms, we characterized the circadian transcriptional regulation across different brain regions and the liver as well as serum metabolomics in mice exposed to chronic social defeat stress, a validated model for studying depressive-like behaviors.

Methods

Male C57BL/6J mice underwent chronic social defeat stress, and subsequent social interaction screening identified distinct behavioral phenotypes associated with stress resilience and susceptibility. Stressed mice and their control lit

SUBMITTER: Savva C 

PROVIDER: S-EPMC11462208 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature