Severity Scale of Diabetic Macular Ischemia Based on the Distribution of Capillary Nonperfusion in OCT Angiography.

ABSTRACT:

Purpose

To evaluate the severity scales of diabetic macular ischemia (DMI) by analyzing the quantity and distribution of capillary nonperfusion using OCT angiography (OCTA) images.

Design

A single-center, prospective case series.

Participants

Three hundred one eyes from 301 patients with diabetic retinopathy.

Methods

We acquired 3 × 3-mm swept-source OCTA images and created en face images within a central 2.5-mm circle. The circle was divided into 15 × 15-pixel squares and nonperfusion squares (NPSs) were defined as those without retinal vessels. Eyes with high-dimensional spatial data were arranged on a 2-dimensional space using the uniform manifold approximation and projection (UMAP) algorithm and classified by clustering into 5 groups: Initial, Mil

SUBMITTER: Yoshida M 

PROVIDER: S-EPMC11462257 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature