Synergy between time-restricted feeding and time-restricted running is necessary to shift the muscle clock in male wistar rats.

ABSTRACT: Circadian disruption is an important factor driving the current-day high prevalence of obesity and type-2 diabetes. While the impact of incorrect timing of caloric intake on circadian disruption is widely acknowlegded, the contribution of incorrect timing of physical activity remains relatively understudied. Here, we modeled the incorrect timing of physical activity in nightshift workers in male Wistar rats, by restricting running wheel access to the innate inactive (light) phase (LR). Controls included no wheel access (NR); access only during the innate active (dark) period (DR); or unrestricted (ad libitum) access (ALR). LR did not shift the phase of the muscle or liver clock, but dampened the muscle clock amplitude. As our previous study demonstrated that light-phase restricted f

SUBMITTER: Shiba A 

PROVIDER: S-EPMC11462373 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature