The GenoPred pipeline: a comprehensive and scalable pipeline for polygenic scoring.

ABSTRACT:

Motivation

Polygenic scoring is an approach for estimating an individual's likelihood of a given outcome. Polygenic scores are typically calculated from genome-wide association study (GWAS) summary statistics and individual-level genotype data for the target sample. Going from genotype to interpretable polygenic scores involves many steps and there are many methods available, limiting the accessibility of polygenic scores for research and clinical application. Additional challenges exist for studies in ancestrally diverse populations. We have implemented the leading polygenic scoring methodologies within an easy-to-use pipeline called GenoPred.

Results

Here, we present the GenoPred pipeline, an easy-to-use, high-performance, reference-standardized, and reproducible workflow

SUBMITTER: Pain O 

PROVIDER: S-EPMC11462442 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature