Identification of key differentially methylated genes regulating muscle development in chickens: insights from Jingyuan breed.

ABSTRACT: Skeletal muscle development is a complex, regulated physiological process that involves myoblast proliferation and differentiation and the fusion of myotubes. In this study, phenotypic differences in the breast and leg muscles of 180-day-old Jingyuan chickens were investigated. Differentially methylated genes (DMG) that regulate muscle development were identified through differential expression analysis and weighted gene co-expression network analysis. Moreover, myoblasts were used as test material and treated with cycloleucine to investigate the effect of N⁶-methyladenosine (m⁶A) modification on their proliferation and differentiation. The results revealed that the myofiber diameter and cross-sectional area in the breast muscle of Jingyuan chickens were significantly

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11462489 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature