Unravelling Microarray Patch Performance: The Role of <i>In Vitro</i> Release Medium and Biorelevant Testing.

ABSTRACT: The absence of established protocols for studying the in vitro performance of dissolvable microarray patches (MAPs) poses a significant challenge within the field. To overcome this challenge, it is essential to optimize testing methods in a way that closely mimics the skin's environment, ensuring biorelevance and enhancing the precision of assessing MAP performance. This study focuses on optimizing in vitro release testing (IVRT) and in vitro permeation testing (IVPT) methods for MAPs containing the antihistamine drugs loratadine (LOR) and chlorpheniramine maleate (CPM). Our primary objective is to investigate the impact of the composition of in vitro release media on the drug release rate, penetration through the skin, and permeation into the release medium. Ar

SUBMITTER: Railic M 

PROVIDER: S-EPMC11462508 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature