Advancing pharmacogenomic research in US Hmong populations: prevalence of key single nucleotide variations in California Hmong.

ABSTRACT:

Introduction

In collaboration with the Minnesota Hmong community, we have previously discovered significant differences in allele frequencies for key Single Nucleotide Variations (SNVs) within Very Important Pharmacogenes (VIPs) between Hmong and East Asians. Recognizing the potential clinical implications of these observed differences, we sought to validate these observations in a Hmong cohort residing in California, the state with the largest Hmong population in the US. Robust validation of these differences would affect motivation for clinicians treating individuals who identify as Hmong to consider pharmacogenomic (PGx) testing as a means to improve clinical decision making when using therapeutic agents in this unique population.

Method

Guided by California Hmong communi

SUBMITTER: Sun B 

PROVIDER: S-EPMC11462547 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature