The efficacy of first and second immunotherapy exposure in patients with recurrent or metastatic cervical cancer.

ABSTRACT:

Objective

Immunotherapy has led to changes in cervical cancer guidelines. Therefore, additional biomarkers to identify the ideal patient who would experience the most benefit may be important.

Methods

We retrospectively collected 208 patients with R/M CC and recorded clinicopathologic information, peripheral blood markers and treatments to analyze the prognostic factors of clinical outcomes. Response rate comparison, univariate, and multivariate analyses were performed to assess the efficacy of different factors.

Results

A total of 43.27% patients achieved objective responses, including 18 with complete response and 72 with partial response. Patients receiving first-line immunotherapy had much higher objective response rate (ORR) than the remaining patients (53.8% vs.

SUBMITTER: Ju M 

PROVIDER: S-EPMC11462590 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature