Examining the effects of the HIV-1 protein Tat and morphine on antiretroviral accumulation and distribution within the brain.

ABSTRACT: Despite combination antiretroviral therapy effectively suppressing HIV within the periphery, neuro-acquired HIV (neuroHIV) remains a significant problem and approximately half of people living with HIV will experience HIV-associated neurocognitive disorders (HAND). Concurrent opioid use exacerbates neuroHIV by promoting neuroinflammation, neuronal injury and synaptodendritic culling, viral replication, and potentially altering antiretroviral concentrations within the brain. The present study examined the effects of HIV and morphine co-exposure on the accumulation and spatial distribution of antiretroviral drugs across multiple regions within the brain in an HIV-1 Tat transgenic mouse model by using infrared-matrix-assisted laser desorption electrospray ionization mass spectrometry imaging

SUBMITTER: Jones AM 

PROVIDER: S-EPMC11462598 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature