Intranasal vs. intramuscular administration of azaperone, midazolam and ketamine in pigs.

ABSTRACT:

Objective

To compare the efficacy of intranasal (IN) and intramuscular (IM) administrations of azaperone (3 mg kg^-1), midazolam (0. 3 mg kg^-1), and ketamine (7 mg kg^-1) combination (AMK) in pigs. Study design: Randomized clinical trial. Animals: sixteen adult male pigs, immunocastrated, of mixed lineage.

Methods

In phase I, these animals were randomly assigned to intranasal (GIN, n = 8) and intramuscular (GIM, n = 8) groups for arterial blood sample collection at 10, 20, 30, 45, 60, and 90 min after AMK administrations for gas and electrolyte analysis. In phase II, performed 1 week after phase I, the 16 pigs were allocated to both groups (GIM, n = 16/GIN, n = 16) and submitted to the same chemical restraint (CR) pr

SUBMITTER: Rabelo IP 

PROVIDER: S-EPMC11462642 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature