Effects of normal saline versus lactated Ringer's solution on organ function and inflammatory responses to heatstroke in rats.

ABSTRACT:

Background

Heatstroke is a life-threatening condition characterized by severe hyperthermia and multiple organ dysfunction. Both normal saline (NS) and lactated Ringer's solution (LR) are commonly used for cooling and volume resuscitation in heatstroke patients; however, their specific impacts on patient outcomes during heatstroke management are poorly understood. Given that the systemic inflammatory response and multiple-organ damage caused by heat toxicity are the main pathophysiological features of heatstroke, the aim of this study was to evaluate the effects of NS and LR on the production of inflammatory cytokines and the functional and structural integrity of renal and cardiac tissues in a rat model of heatstroke.

Methods

Fifty-five male Sprague‒Dawley rats were randomly

SUBMITTER: Chen L 

PROVIDER: S-EPMC11462651 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature