Cortical morphological changes and associated transcriptional signatures in post-traumatic stress disorder and psychological resilience.

ABSTRACT:

Background

Individuals who have experienced severe traumatic events are estimated to have a post-traumatic stress disorder (PTSD) prevalence rate ranging from 10 to 50%, while those not affected by trauma exposure are often considered to possess psychological resilience. However, the neural mechanisms underlying the development of PTSD, especially resilience after trauma, remain unclear. This study aims to investigate changes of cortical morphometric similarity network (MSN) in PTSD and trauma-exposed healthy individuals (TEHI), as well as the associated molecular alterations in gene expression, providing potential targets for the prevention and intervention of PTSD.

Methods

We recruited PTSD patients and TEHI who had experienced severe earthquakes, and healthy controls who

SUBMITTER: Yuan M 

PROVIDER: S-EPMC11462656 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature