HLA diversity unveils susceptibility and organ-specific occurrence of second primary cancers: a prospective cohort study.

ABSTRACT:

Background

Up to 17% of cancer survivors have been reported to develop second primary cancers (SPC), which cause significant physical and economic distress and often complicate clinical decision-making. However, understanding of SPC remains limited and superficial. Human leukocyte antigen (HLA) is characterized by its polymorphism and has been associated with various diseases. This study aims to explore the role of HLA diversity in SPC incidence.

Methods

We analyzed a cohort of 47,550 cancer patients from the UK Biobank. SNP-derived HLA alleles were used and SPC-related HLA alleles were identified using logistic regression, followed by stepwise filtering based on the Akaike information criterion (AIC) and permutation tests. Additionally, we examined the association between e

SUBMITTER: Rong ZX 

PROVIDER: S-EPMC11462672 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature