Pediatric migraine is characterized by traits of ecological and metabolic dysbiosis and inflammation.

ABSTRACT:

Background

Recently, there has been increasing interest in the possible role of the gut microbiota (GM) in the onset of migraine. Our aim was to verify whether bacterial populations associated with intestinal dysbiosis are found in pediatric patients with migraine. We looked for which metabolic pathways, these bacteria were involved and whether they might be associated with gut inflammation and increased intestinal permeability.

Methods

Patients aged between 6 and 17 years were recruited. The GM profiling was performed by the 16S rRNA metataxonomics of faecal samples from 98 patients with migraine and 98 healthy subjects. Alpha and beta diversity analyses and multivariate and univariate analyses were applied to compare the gut microbiota profiles between the two group. To pr

SUBMITTER: Papetti L 

PROVIDER: S-EPMC11462686 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature