Elucidating the power of arginine restriction: taming type I interferon response in breast cancer via selective autophagy.

ABSTRACT:

Background

Type I interferons (IFN-I) are potent alarm factors that initiate cancer cell elimination within tumors by the immune system. This critical immune response is often suppressed in aggressive tumors, thereby facilitating cancer immune escape and unfavorable patient outcome. The mechanisms underpinning IFN-I suppression in tumors are incompletely understood. Arginase-1 (ARG1)-expressing immune cells that infiltrate tumors can restrict arginine availability by ARG1-mediated arginine degradation. We hypothesized that arginine restriction suppresses the IFN-I response in tumors.

Methods

Comprehensive, unbiased open approach omics analyses, various in vitro techniques, including microscopy, qPCR, immunoblotting, knock-down experiments, and flow cytometry were employed, a

SUBMITTER: Lamsal A 

PROVIDER: S-EPMC11462705 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature