Blood trauma in veno-venous extracorporeal membrane oxygenation: low pump pressures and low circuit resistance matter.

ABSTRACT:

Background

Veno-venous extracorporeal membrane oxygenation (VV ECMO) has become standard of care in patients with the most severe forms of acute respiratory distress syndrome. However, hemolysis and bleeding are one of the most frequent side effects, affecting mortality. Despite the widespread use of VV ECMO, current protocols lack detailed, in-vivo data-based recommendations for safe ECMO pump operating conditions. This study aims to comprehensively analyze the impact of VV ECMO pump operating conditions on hemolysis by combining in-silico modeling and clinical data analysis.

Methods

We combined data from 580 patients treated with VV ECMO in conjunction with numerical predictions of hemolysis using computational fluid dynamics and reduced order modeling of the Rotaflow (Get

SUBMITTER: Blum C 

PROVIDER: S-EPMC11462722 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature