CGF therapy: bridging androgenetic alopecia observations to psoriasis treatment via IL-17 pathway.

ABSTRACT:

Introduction

Concentrated Growth Factor (CGF), rich in CD34 + stem cells, is widely used in treatments for androgenetic alopecia and skin rejuvenation due to its immune-modulating properties. Psoriasis, a chronic inflammatory skin condition, presents significant treatment challenges, particularly for patients who cannot use biologics due to conditions such as cancer and lesions resistant to treatments. The potential of CGF in treating psoriasis is promising, given its broad immunoregulatory effects which confirmed in our previous androgenetic alopecia work.

Methods

We evaluated the impact of CGF on IL-17 levels in two contexts: patients treated for androgenetic alopecia and a psoriasis mouse model. Twelve patients received three monthly injections of CGF, with serum IL-17 le

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC11462746 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature