Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study.

ABSTRACT:

Background

There is a substantial body of observational research indicating an association between hearing impairment and dementia, yet the causal relationship and underlying mechanisms remain uncertain. This study aims to investigate the causal relationship between hearing impairment and its subtypes with dementia and cognitive function using two-sample Mendelian randomization (MR) analysis.

Methods

We performed two-sample MR analysis to examine the causal effects of hearing impairment and its subtypes, including conductive and sensorineural hearing loss (CSHL), conductive hearing loss (CHL), sensorineural hearing loss (SHL), and sudden sensorineural hearing loss (SIHL), on six dementia phenotypes (overall dementia, Alzheimer's disease [AD], Lewy body dementia [DLB], fronto

SUBMITTER: Jiang D 

PROVIDER: S-EPMC11462771 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature