Vasoactive intestinal peptide promotes secretory differentiation and mitigates radiation-induced intestinal injury.

ABSTRACT:

Background

Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal epithelial cell turnover and differentiation remains less understood. Intestinal stem and progenitor cells are essential for the maintenance of intestinal homeostasis and regeneration, and their functions can be modulated by factors of the stem cell niche, including neuronal mediators. Here, we investigated the role of VIP in regulating intestinal epithelial homeostasis and regeneration following irradiation-induced injury.

Methods

Jejunal organoids were derived from male and femal

SUBMITTER: Agibalova T 

PROVIDER: S-EPMC11462795 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature