Evaluation of urinary podocin and nephrin as markers of podocyturia in dogs with leishmaniosis.

ABSTRACT:

Background

Renal disease is the main cause of death in canine leishmaniosis. Detection of an active glomerular injury is important to identify early renal damage and to prevent the development of chronic kidney disease. Podocyturia can indicate renal injury, and podocyte-associated molecules such as podocin and nephrin can be used to identify podocyturia. The purpose of the study was to evaluate urinary podocin and nephrin concentrations in dogs with leishmaniosis as markers of podocyturia.

Methods

A total of 35 healthy dogs and 37 dogs with leishmaniosis were enrolled in the study. Dogs with leishmaniosis were classified according to the staging of the International Renal Interest Society (IRIS). Urinary podocin and nephrin concentrations were measured in all dogs with a va

SUBMITTER: Pantaleo V 

PROVIDER: S-EPMC11462908 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature