Peripartum depression symptom trajectories, telomere length and genotype, and adverse childhood experiences.

ABSTRACT:

Background

As a biological marker for cellular senescence, telomere length (TL) has been linked to a variety of psychiatric disorders and adverse childhood experiences (ACE), though only preliminarily to peripartum depression (PPD). The present study sought to examine the association between TL and PPD, assessing the moderating role of ACE and genetic polymorphic variations related with the telomere machinery.

Methods

Adversity was self-reported, likewise were depressive symptoms evaluated at pregnancy week 17 and 32, as well as six-weeks and six-months postpartum. TL was assessed by use of qPCR in blood samples collected during delivery from females with antenatal depression resolving postpartum, females with depression persisting to postpartum, and healthy controls. Twenty

SUBMITTER: Vrettou M 

PROVIDER: S-EPMC11462957 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature