Salivary metabolomic biomarkers for esophageal and gastric cancers by liquid chromatography-mass spectrometry.

ABSTRACT: Early detection of esophageal and gastric cancers is essential for patients' prognosis; however, optimal noninvasive screening tests are currently not available. Saliva is a biofluid that is readily available, allowing for frequent screening tests. Thus, we explored salivary diagnostic biomarkers for esophageal and gastric cancers using metabolomic analyses. Saliva samples were collected from patients with esophageal (n = 50) and gastric cancer (n = 63), and patients without cancer as controls (n = 20). Salivary metabolites were analyzed by liquid chromatography-mass spectrometry to identify salivary biomarkers. We also examined the metabolic profiles of gastric cancer tissues and compared them with the salivary biomarkers. The sensitivity of the diagnostic models based on salivary biomark

SUBMITTER: Nakane K 

PROVIDER: S-EPMC11463073 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature