Plasma metabolomics profiles and breast cancer risk.

ABSTRACT:

Background

Breast cancer (BC) is the most common cancer in women and incidence rates are increasing; metabolomics may be a promising approach for identifying the drivers of the increasing trends that cannot be explained by changes in known BC risk factors.

Methods

We conducted a nested case-control study (median followup 6.3 years) within the New York site of the Breast Cancer Family Registry (BCFR) (n = 40 cases and 70 age-matched controls). We conducted a metabolome-wide association study using untargeted metabolomics coupling hydrophilic interaction liquid chromatography (HILIC) and C₁₈ chromatography with high-resolution mass spectrometry (LC-HRMS) to identify BC-related metabolic features.

Results

We found eight metabolic features associated with BC ri

SUBMITTER: Wu HC 

PROVIDER: S-EPMC11463119 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature