Molecular targets and strategies in the development of nucleic acid cancer vaccines: from shared to personalized antigens.

ABSTRACT: Recent breakthroughs in cancer immunotherapies have emphasized the importance of harnessing the immune system for treating cancer. Vaccines, which have traditionally been used to promote protective immunity against pathogens, are now being explored as a method to target cancer neoantigens. Over the past few years, extensive preclinical research and more than a hundred clinical trials have been dedicated to investigating various approaches to neoantigen discovery and vaccine formulations, encouraging development of personalized medicine. Nucleic acids (DNA and mRNA) have become particularly promising platform for the development of these cancer immunotherapies. This shift towards nucleic acid-based personalized vaccines has been facilitated by advancements in molecular techniques for identi

SUBMITTER: Chi WY 

PROVIDER: S-EPMC11463125 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature