Lipid-lowering drugs and risk of rapid renal function decline: a mendelian randomization study.

ABSTRACT:

Background

Chronic kidney disease (CKD) patients face the risk of rapid kidney function decline leading to adverse outcomes like dialysis and mortality. Lipid metabolism might contribute to acute kidney function decline in CKD patients. Here, we utilized the Mendelian Randomization approach to investigate potential causal relationships between drug target-mediated lipid phenotypes and rapid renal function decline.

Methods

In this study, we utilized two methodologies: summarized data-based Mendelian randomization (SMR) and inverse variance-weighted Mendelian randomization (IVW-MR), to approximate exposure to lipid-lowering drugs. This entailed leveraging expression quantitative trait loci (eQTL) for drug target genes and genetic variants proximal to drug target gene regions,

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC11463126 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature