Microfluidic Modulation of Microvasculature in Microdissected Tumors.

ABSTRACT: The microvasculature within the tumor microenvironment (TME) plays an essential role in cancer signaling beyond nutrient delivery. However, it has been challenging to control the generation and/or maintenance of microvasculature in ex vivo systems, a critical step for establishing cancer models of high clinical biomimicry. There have been great successes in engineering tissues incorporating microvasculature de novo (e.g., organoids and organs-on-chip), but these reconstituted tissues are formed with non-native cellular and molecular components that can skew certain outcomes such as drug efficacy. Microdissected tumors, on the other hand, show promise in preserving the TME, which is key for creating cancer models that can bridge the gap between bench and bedside. Howeve

SUBMITTER: Nguyen TNH 

PROVIDER: S-EPMC11463410 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature