Multi-omics identification of extracellular components of the fetal monkey and human neocortex.

ABSTRACT: During development, precursor cells are continuously and intimately interacting with their extracellular environment, which guides their ability to generate functional tissues and organs. Much is known about the development of the neocortex in mammals. This information has largely been derived from histological analyses, heterochronic cell transplants, and genetic manipulations in mice, and to a lesser extent from transcriptomic and histological analyses in humans. However, these approaches have not led to a characterization of the extracellular composition of the developing neocortex in any species. Here, using a combination of single-cell transcriptomic analyses from published datasets, and our proteomics and immunohistofluorescence analyses, we provide a more comprehensive and unbiased

SUBMITTER: Vilicich F 

PROVIDER: S-EPMC11463417 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature