Motility-dependent processes in <i>Toxoplasma gondii</i> tachyzoites and bradyzoites: same same but different.

ABSTRACT: The tachyzoite stage of the apicomplexan parasite Toxoplasma gondii utilizes motility for multiple purposes during its lytic cycle, including host cell invasion, egress from infected cells, and migration to new uninfected host cells to repeat the process. Bradyzoite stage parasites, which establish a new infection in a naïve host, must also use motility to escape from the cysts that are ingested by the new host and then migrate to the gut wall, where they either invade cells of the intestinal epithelium or squeeze between these cells to infect the underlying connective tissue. We know very little about the motility of bradyzoites, which we analyze in detail here and compare to the well-characterized motility and motility-dependent processes of tachyzoites. Unexpectedly, bradyzoites

SUBMITTER: Kent RS 

PROVIDER: S-EPMC11463423 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature