Reproducible Sex Differences in Personalized Functional Network Topography in Youth.

ABSTRACT:

Background

A key step towards understanding psychiatric disorders that disproportionately impact female mental health is delineating the emergence of sex-specific patterns of brain organization at the critical transition from childhood to adolescence. Prior work suggests that individual differences in the spatial organization of functional brain networks across the cortex are associated with psychopathology and differ systematically by sex.

Aims

We aimed to evaluate the impact of sex on the spatial organization of person-specific functional brain networks.

Method

We leveraged person-specific atlases of functional brain networks defined using nonnegative matrix factorization in a sample of n = 6437 youths from the Adolescent Brain Cognitive Development Study. Ac

SUBMITTER: Keller AS 

PROVIDER: S-EPMC11463432 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature