Charting cortical-layer specific area boundaries using Gibbs' ringing attenuated T1w/T2w-FLAIR myelin MRI.

ABSTRACT: Cortical areas have traditionally been defined by their distinctive layer cyto- and/or myelo- architecture using postmortem histology. Recent studies have delineated many areas by measuring overall cortical myelin content and its spatial gradients using the T1w/T2w ratio MRI in living primates, including humans. While T1w/T2w studies of areal transitions might benefit from using the layer profile of this myelin-related contrast, a significant confound is Gibbs' ringing artefact, which produces signal fluctuations resembling cortical layers. Here, we address these issues with a novel approach using cortical layer thickness-adjusted T1w/T2w-FLAIR imaging, which effectively cancels out Gibbs' ringing artefacts while enhancing intra-cortical myelin contrast. Whole-brain MRI measures were mappe

SUBMITTER: Autio JA 

PROVIDER: S-EPMC11463467 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature