Neural substrates for saccadic modulation of visual representations in mouse superior colliculus.

ABSTRACT: How do sensory systems account for stimuli generated by natural behavior? We addressed this question by examining how an ethologically relevant class of saccades modulates visual representations in the mouse superior colliculus (SC), a key region for sensorimotor integration. We quantified saccadic modulation by recording SC responses to visual probes presented at stochastic saccade-probe latencies. Saccades significantly impacted population representations of the probes, with early enhancement that began prior to saccades and pronounced suppression for several hundred milliseconds following saccades, independent of units' visual response properties or directional tuning. To determine the cause of saccadic modulation, we presented fictive saccades that simulated the visual experience durin

SUBMITTER: Hunt JB 

PROVIDER: S-EPMC11463470 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature