Adipocyte metabolic state regulates glial phagocytic function.

ABSTRACT: Obesity and type 2 diabetes are well-established risk factors for neurodegenerative disorders^1-4, yet the underlying mechanisms remain poorly understood. The adipocyte-brain axis is crucial for brain function, as adipocytes secrete signaling molecules, including lipids and adipokines, that impinge on neural circuits to regulate feeding and energy expenditure⁵. Disruptions in the adipocyte-brain axis are associated with neurodegenerative conditions⁶, but the causal links are not fully understood. Neural debris accumulates with age and injury, and glial phagocytic function is crucial for clearing this debris and maintaining a healthy brain microenvironment^7-9. Using adult Drosophila, we investigate how adipocyte metabolism influences glial p

SUBMITTER: Alassaf M 

PROVIDER: S-EPMC11463506 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature