Maintenance of memory by negative-feedback of synaptic protein elimination: Modeling KIBRA- P K M ζ dynamics in LTP.

ABSTRACT: Activity-dependent modifications of synaptic efficacies are a cellular substrate of learning and memory. Current theories propose that the long-term maintenance of synaptic efficacies and memory is accomplished via a positive-feedback loop at the level of production of a protein species or a protein state. Here we propose a qualitatively different theoretical framework based on negative feedback at the level of protein elimination. This theory is motivated by recent experimental findings regarding the binding of PKMζ and KIBRA, two synaptic proteins involved in maintenance of memory, and on how this binding downregulates the proteins' degradation. We demonstrate this theoretical framework with two different models. First, a simple abstract model to explore generic features of the negative-

SUBMITTER: Shouval HZ 

PROVIDER: S-EPMC11463625 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature