Capturing sclera anisotropy using direct collagen fiber models. Linking microstructure to macroscopic mechanical properties.

ABSTRACT: Because of the crucial role of collagen fibers on soft tissue mechanics, there is great interest in techniques to incorporate them in computational models. Recently we introduced a direct fiber modeling approach for sclera based on representing the long-interwoven fibers. Our method differs from the conventional continuum approach to modeling sclera that homogenizes the fibers and describes them as statistical distributions for each element. At large scale our method captured gross collagen fiber bundle architecture from histology and experimental intraocular pressure-induced deformations. At small scale, a direct fiber model of a sclera sample reproduced equi-biaxial experimental behavior from the literature. In this study our goal was a much more challenging task for the direct fiber mod

SUBMITTER: Ji F 

PROVIDER: S-EPMC11463644 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature