Advancing insights in critical COVID-19: unraveling lymphopenia through propensity score matching - Findings from the Multicenter LYMPH-COVID Study.

ABSTRACT:

Objective

To elucidate the impact of lymphopenia on critical COVID-19 patient outcomes.

Methods

We conducted a multicenter prospective cohort study across five hospitals in Portugal and Brazil from 2020 to 2021. The study included adult patients admitted to the intensive care unit with SARS-CoV-2 pneumonia. Patients were categorized into two groups based on their lymphocyte counts within 48 hours of intensive care unit admission: the Lymphopenia Group (lymphocyte serum count < 1 × 109/L) and the Nonlymphopenia Group. Multivariate logistic regression, propensity score matching, Kaplan‒Meier survival curve analysis and Cox proportional hazards regression analysis were used.

Results

A total of 912 patients were enrolled, with 191 (20.9%) in the Nonlymphopenia Group and 7

SUBMITTER: Cidade JP 

PROVIDER: S-EPMC11463993 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature