Casual associations between brain structure and sarcopenia: A large-scale genetic correlation and mendelian randomization study.

ABSTRACT: Sarcopenia presenting a critical challenge in population-aging healthcare. The elucidation of the interplay between brain structure and sarcopenia necessitates further research. The aim of this study is to explore the casual association between brain structure and sarcopenia. Linkage disequilibrium score regression (LDSC) was conducted to estimate the genetic correlations; MR was then performed to explore the causal relationship between Brain imaging-derived phenotypes (BIDPs) and three sarcopenia-related traits: handgrip strength, walking pace, and appendicular lean mass (ALM). The main analyses were conducted using the inverse-variance weighted method. Moreover, weighted median and MR-Egger were conducted as sensitivity analyses. Genetic association between 6.41% of BIDPs and ALM was obs

SUBMITTER: Yang G 

PROVIDER: S-EPMC11464103 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature