Accumulation of DNA G-quadruplex in mitochondrial genome hallmarks mesenchymal senescence.

ABSTRACT: Searching for biomarkers of senescence remains necessary and challenging. Reliable and detectable biomarkers can indicate the senescence condition of individuals, the need for intervention in a population, and the effectiveness of that intervention in controlling or delaying senescence progression and senescence-associated diseases. Therefore, it is of great importance to fulfill the unmet requisites of senescence biomarkers especially when faced with the growing global senescence nowadays. Here, we established that DNA G-quadruplex (G4) in mitochondrial genome was a reliable hallmark for mesenchymal senescence. Via developing a versatile and efficient mitochondrial G4 (mtG4) probe we revealed that in multiple types of senescence, including chronologically healthy senescence, progeria, and

SUBMITTER: Yu K 

PROVIDER: S-EPMC11464107 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature