3D printed scaffolds with quercetin and vitamin D3 nanocarriers: In vitro cellular evaluation.

ABSTRACT: Increasing bone diseases and anomalies significantly challenge bone regeneration, necessitating the development of innovative implantable devices for effective healing. This study explores the potential of 3D-printed calcium phosphate (CaP) scaffolds functionalized with natural medicine to address this issue. Specifically, quercetin and vitamin D3 (QVD) encapsulated solid lipid nanoparticles (QVD-SLNs) are incorporated into the scaffold to enhance bone regeneration. The melt emulsification method is utilized to achieve high drug encapsulation efficiency (~98%) and controlled biphasic release kinetics. The process-structure-property performance of these systems allows more controlled release while maintaining healthy cell-material interactions. The functionalized scaffolds show ~1.3- and ~-

SUBMITTER: Bose S 

PROVIDER: S-EPMC11464199 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature